1. Chronic long-term therapy of myastheniagravis is usually accomplished with:
A. Edrophonium
B. Neostigmine
C. Echothiophate
D. Carbachol
2. Which of the following cholinomimetics is used in the treatment of atropine
intoxication?
A. Neostigmine
B. Carbachol
C. Physostigmine
D. Lobeline
3. Which neuromuscular blocking agent has the potential to cause the greatest release of
histamine?
A. Succinylcholine
B. Tubocurarine
C. Pancuronium
D. Rocuronium
4. Which of the following neuromuscular blocking agents cause cardiac arrhythmias?
A. Vecuronium
B. Tubocurarine
C. Rapacuronium
D. Succinylcholine
Solution of Brain Ticklers:
1. B. Neostigmine- Neostigmine and Pyridostigmine a class of medications called
acetylcholinestrase inhibitors, typically taken every 4-6 hours, which treat just the symptoms
associated with Myasthenia gravis. They can enhance the transmission of nerve impulses and
increase muscle strength.
2. C. Physostigmine- Atropine causes anticholinergic toxicity; physostigmine reverses this by
inhibiting acetylcholinestrase, given I. V.
3. B. Tubocurarine- d-tubocurarine causes the most histamine release by a direct effect on mast
cells, it is contraindicated in asthmatics and patients with allergies.
4. D. Succinylcholine is an ultra-short-acting depolarizing-type, skeletal muscle relaxant for
intravenous (IV) administration succinylcholine may induce serious cardiac arrhythmias or
cardiac arrest due to hyperkalemia
