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Thursday, December 26, 2019
Saturday, December 21, 2019
IIT-B scientists now develop cheaper tech to cure cancer
Source: THE TIMES OF INDIA-21st December,2019
In a
breakthrough in research, IIT-Bombay scientists have developed technology to
leverage a patient’s immune system to cure cancer. Such immunotherapy using CAR
T-cells, a treatment for cancer, which costs Rs 3-4 crore in US, can be made
available for Rs 15 lakh, if the technology is developed in the country.
Researchers made use of gene and cell therapies to
reengineer immune cells to attack and kill cancer cells in the body. The
treatment is less painful than surgery, chemotherapy or radiation, and is known
to lower chances of a relapse. The therapy, which seems promising in the
treatment of cancer, especially leukaemia, is currently not available in India.
With the growing burden of cancer in the country, success in even a fraction of
the patients using the technique will be remarkable, experts said.
Prof Rahul Purwar and his team of scientists from the
institute’s Department of Biosciences and Bioengineering have conducted
laboratory tests and hope to start clinical trials in collaboration with Dr
Gaurav Narula from Tata Memorial Hospital (TMH) next year, after getting
permission from Drug Controller General of India (DCGI). A facility has been
created for it at the hospital’s Kharghar campus.
T-cells (type of white blood cell or WBC), an integral part
of the human immune system, can identify tumours and destroy them. But in
advanced stages, the cancer cells adapt to the presence of T-cells and remain
undetected. In the new approach in immunotherapy, called CAR (chimeric antigen
receptors) T-cell therapy, the T-cells’ ability to detect and kill cancer cells
is restored. CARs are protein that assist T-cells to recognise and attach to
protein or antigen, present on cancer cells. These proteins help destroying
cancer cells.
Purwar’s team has been working on CAR T-cell technology for
six years. “It is an autologous cell therapy for personalised medicine, where
cells are taken from patients, re-engineered and re-infused in the patient. We
got immune cells from volunteers and clinical patients with help from TMH and
re-engineered them using the technique. The modified cells were positively
tested in laboratories on artificially grown cancer cells,” said Purwar.
“Our team has delved into strategies that would improve
efficacy of the technique and demonstrated that a single injected dose can lead
to multiplication of modified Tcells that can destroy cancer cells,” said
Purwar.
A private firm is planning to in-licence the technology and
is trying to make the therapy available for Indian patients for about Rs 35
lakh. Purwar and two researchers are working on the technology as part of their
start-up ImmunoAdaptive Cell Therapy or ImmunoACT, which was incubated at
IIT-B.
Globally, over 600 clinical trials are in progress for CAR
T-cell therapy, many of which are on in China, said Dr Narula from TMH.
“It has got huge potential. With the cancer burden we have,
the therapy will be considered a success, even if it applicable to only a
fraction of patients currently. Technologies are being developed globally, but
are exorbitant. The only way to cut costs is by developing the technology in
India, which is why we have teamed up with IIT-B about four and a half years
ago, long before the first therapy was approved for clinical use in US. There
are high expectations from this technology as it can create pathways for
developing newer technologies, for newer therapies, for more forms of cancer.
Thousands of Asians can benefit,” said Narula.
He added that the therapy’s side effects can be managed. “It
has worked on patients where two lines of treatments have failed. Even in the
limited group, it works spectacularly,” said Narula.
Friday, December 20, 2019
How a 17-year-old student is helping eliminate middlemen from medicine sales
Source:
https://www.businesstoday.in/sectors/pharma/how-a-17-year-old-student-is-helping-eliminate-middlemen-from-medicine-sales/story/392327.html
https://www.businesstoday.in/sectors/pharma/how-a-17-year-old-student-is-helping-eliminate-middlemen-from-medicine-sales/story/392327.html
Arjun Deshpande's unique pharmacy chain Generic Aadhar sells generic medicines to the masses at much cheaper rates than the market price
Most of India's young entrepreneurs come from the IT sector, and not many
from the pharma. However, a 17-year old 12th class student Arjun Deshpande is
different. Earlier this year, Deshpande founded a pharmacy retailing chain
Generic Aadhar with an aim to sell generic medicines to the masses at much
cheaper rates than the market price (generics are sold at almost 40 per cent
premium to the ex-factory cost).
His unique pharmacy aggregator business model is to source generic drugs
directly from the manufacturers and give it to the retail pharmacies,
eliminating the 16-20 per cent wholesaler margin along with other layers of
margins such as C&F agents in the trade. Already about a dozen retailers,
who were finding it difficult to cope with the intense competition from
established medical stores on one side and the deep discounted sales strategy
of online pharmacies on the other, have joined the Generic Aadhar fold. The
stores are offered a free face-lift with Generic Aadhar branding, logo and the
requisite IT infrastructure with links to the head office in Thane. The Generic
Aadhar has about a dozen employees, which includes pharmacists, IT engineers
and marketing specialists who 'educate the customers' on generic drugs and its
advantages.
"We started operations in March. Our average monthly revenues of
branded stores have doubled as drugs are sold at much cheaper rates than
those in their neighbourhood pharmacies," says Deshpande, who often bunks
his school for 'business and networking'. Currently Generic Aadhaar has tied up
with four Mumbai-based WHO-GMP certified manufacturers to procure drugs with
over a dozen medical stores in Mumbai and Pune joining the franchisee network.
"We have a profit sharing model with the pharmacies and already Generic
Aadhar has done over Rs 40 lakh business," says Deshpande, who has been
shortlisted for the Thiel Fellowship in Silicon Valley, a two-year program for
young people who want to build new business ideas.
Over the next three-four months, plans are to extend the franchisee pharmacy
network to 30-40 pharmacies in Maharashtra, Goa and Gujarat. Deshpande says he
started the business with funding from his parents, who have their own business
ventures. His mother runs a pharmaceutical marketing company, which sells drugs
in international markets and father runs a tour and travel agency.
"The next round of expansions will require about $3-5 million and a
leading well-known retailer has agreed to invest as a strategic investor, which
may happen over the next few months," says the young entrepreneur, who got
this business idea while travelling with his mother during a summer vacation to
the US, Dubai and a few other countries to attend pharmaceutical trade events.
"India provides generic drugs to the world and in many of those markets, the
margins are much lower than what they have in India," he says.
Besides scaling up the business and increasing the product basket,
Generic Aadhar is also developing a dedicated IT platform for drugs sales so
that drugs can be ordered online and delivered within 'two hours' from the
nearest Generic Aadhar pharmacy.
Thursday, December 19, 2019
Wednesday, December 18, 2019
Monday, December 16, 2019
MMRC Recruitment 2019: Apply online for Architect and Various Engineering post in Mumbai Metro
Source:
https://www.metrorailnews.in/mmrc-recruitment-2019-apply-online-for-architect-and-various-engineering-post-in-mumbai-metro/
https://www.metrorailnews.in/mmrc-recruitment-2019-apply-online-for-architect-and-various-engineering-post-in-mumbai-metro/
MUMBAI (Metro Rail News): Mumbai Metro Rail Corporation (MMRC)
Limited intends to appoint qualified and experienced professionals for the
following posts on Contract / Deputation basis:
MMRC Recruitment 2019 Vacancies
1. Dy. Town Planner:
02 vacancies, Pay Scale: ₹60000 – 180000/- (E3)
2. Dy. Engineer-I (MEP) – Elect. &
Mech. : 01 vacancy, Pay Scale: ₹60000 –
180000/- (E3)
3. Architect:
01 vacancy, Pay Scale: ₹60000 – 180000/- (E3)
4. Dy. Engineer (Civil):
01 vacancy, Pay Scale: ₹50000 – 160000/- (E2)
5. Accounts Officer:
02 vacancies, Pay Scale: ₹50000 – 160000/- (E2)
6. Jr. Engineer-I (MEP) – Elect. &
Mech. : 03 vacancies, Pay Scale: ₹35280 –
67920/- (W6)
7. Deputy Accountant:
04 vacancies, Pay Scale: ₹34020 – 64310/- (W5)
How to Apply for MMRC Recruitment 2019
Eligible candidates may apply online on prescribed format at
MMRC website from 10/12/2019 to 24/01/2020 only for
Government Job Vacancy Recruitment in MMRCL 2019.
Detailed information and online application format Please visit the Career section of MMRCL website at https://www.mmrcl.com/en/careers for details of Government Job Vacancy Recruitment in MMRCL 2019 and online application format.
MHT CET For Engineering Admission Scheduled In April 2020 State CET Cell, Maharashtra has released the tentative schedule for the various Common Entrance Tests (CETs) it would be conducting in the academic year 2020-21.
Source:
https://www.ndtv.com/education/mht-cet-2020-in-april-next-year-detailed-schedule-here-2143690
https://www.ndtv.com/education/mht-cet-2020-in-april-next-year-detailed-schedule-here-2143690
State Common Entrance Test Cell, Maharashtra has released
the tentative schedule for the various Common Entrance Tests (CETs) it would be
conducting in the academic year 2020-21. Following in the lines of National
Testing Agency, which conducts several national-level examinations, Maharashtra
CET Cell has also decided to conduct the entrance tests entirely in the
computer-based mode this year.
MHT CET 2020 which will be held for admission to Bachelor in
Engineering/ Technology (B.E/B.Tech)/ Bachelor in Pharmacy (B.Pharm/Pharm.D),
Agriculture & Allied Courses/ Fisheries Science/ Dairy Technology, is
scheduled in April next year. The examination will be held from April 13 to
April 17, 2020 and April 20 to April 23, 2020.
MAH MBA/MMS CET 2020 which is conducted for admission to
Master in Business Administration and Master in Management Studies will be held
in March 2020, on March 14 and 15.
MAH MCA-CET 2020 which is conducted for admission to Master
in Computer Applications will be held on March 28, 2020.
MAH M.Arch-CET 2020 which is conducted for admission to
Master of Architecture will be held on May 10, 2020.
MAH B.HMCT 2020 which is conducted for admission to Bachelor
of Hotel Management and Catering Technology will also be held on May 10, 2020.
MAH M.HMCT 2020 which is conducted for admission to Master
of Hotel Management and Catering Technology will be held on May 16, 2020.
State CET Cell has also instructed other exam bodies and
educational institutes in Maharashtra to schedule their CETs or examinations
keeping in mind the schedule of the CETs. All further updates on the examinations
will be released only on the Maharashtra CET Cell website, 'mahacet.org'.
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